Djokovic, Muguzura, Nadal in action at French Open

Serbia's Novak Djokovic reacts as he plays Portugal's Joao Sousa during their second round match of the French Open tennis tournament at the Roland Garros stadium Wednesday

Muguruza did not take kindly to the way spectators pulled for her opponent - her French opponent, mind you - so after her title defense ended with a 6-1, 3-6, 6-3 loss to 13th-seeded Kristina Mladenovic at a packed and rowdy Court Suzanne Lenglen, Muguruza walked toward the locker room while wagging a finger toward the stands, as if to say, "Tsk, tsk!"

Seven-time major champion Venus Williams is bidding for a quarterfinal spot against No. 30 Timea Bacsinszky. Her best French Open showing was in 2002, when she lost to Serena in the final.

Defending French Open champion Garbine Muguruza of Spain broke down in her postmatch news conference after being knocked out of the tournament in the round of 16, but gamely returned after a brief break.

The only other two women with a grand slam trophy on their resumes who made it to the fourth round - Svetlana Kuznetsova and Australia's Samantha Stosur - lost earlier Sunday to women without one. Williams committed 45 unforced errors in the defeat. I just think it's normal that it's such an unbelievable atmosphere. "You know, sometimes it's just bad luck". Add it all up, and it means that there will be a first-time major title victor at the end of the tournament. Even though she won on Sunday, she added a big contribution to that total.

In the decider it was Muguruza who failed to capitalize on Mladenovic's serving woes in the third set, and that was ultimately the difference that didn't quite seem over until the last ball was struck.

Teenager Jelena Ostapenko is the first woman from Latvia to make it to the French Open quarterfinals in the professional era. I love playing here.

She might lead the tournament in terms of double faults, having served 40 of them since it started - 16 yesterday. Through the match I was getting more and more.

"It's not ideal, there are little problems but I fight as I can".

"It's not flawless, there are little problems but I fight as I can. you give me so much strength", added the 24-year-old.

Fourth-seed Rafa Nadal continued his ominous march towards a potential 10th French Open title by beating compatriot Roberto Bautista Agut 6-1 6-2 6-2 to reach the last eight.

"When I was on my chair at that point, I thought it was over, but you gave me strength", she told the crowd.

Mladenovic often played to the fans, waving her arms to ask for more noise. "It's very important for me to be in the quarterfinals one more time", said Nadal. "I think he deserves it".

Caroline Wozniacki and Cici Bellis will have to try again on Saturday after their match was called off because of rain with Wozniacki leading 6-2 2-5.

The 47th-ranked Ostapenko is the youngest player in the tournament at age 19. But especially on clay, I've never passed the second here.

"Emotionally I'm quite high at the moment, but it's something I like".

Pliskova doesn't want to hear chatter about now being the favorite as she openly admits clay isn't her favorite surface. "So every match for me is tough and it doesn't matter if she's (ranked) 60 or if she's 300". I mean, I love playing here. It's good, but I can still improve. "It's important that each match I've played here has not been easy".

The 26-year-old Martic next faces fifth-seeded Elina Svitolina after the Ukrainian beat Magda Linette 6-4, 7-5.

Third seed Stan Wawrinka, the 2015 champion, faces a tricky match against Italian 28th seed Fabio Fognini and Japanese eighth seed Kei Nishikori is expected to advance at the expense of South Korea's Chung Hyeon. "I knew I had to change something to beat him today, so I think I made some adjustments to make little better than yesterday". "I also believe that you kind of attract, you know, certain things that when you are, you know, living under stress and fear of everything".

Second seed Karolina Pliskova advanced to round four with a 7-5, 6-1 victory over Germany's Carina Witthoeft.

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